Rabbit articular cartilage defects treated by allogenic chondrocyte transplantation
نویسندگان
چکیده
منابع مشابه
Chondrocyte apoptosis in the regenerated articular cartilage after allogenic chondrocyte transplantation in the rabbit knee.
We attempted to repair full-thickness defects in the articular cartilage of the trochlear groove of the femur in 30 rabbit knee joints using allogenic cultured chondrocytes embedded in a collagen gel. The repaired tissues were examined at 2, 4, 8, 12 and 24 weeks after operation using histological and histochemical methods. The articular defect filling index measurement was derived from safrani...
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To compare the ability of the cartilage precursor cells derived from allogenic and autologous bone marrow mesenchymal stem cells (MSCs) respectively seeded onto “two-phase” allogeneic bone matrix gelatin (BMG) for constructing tissue engineered cartilage in the repair of articular cartilage defects and to observe the repairing efficacy of the two composites for providing the basis for the clini...
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Background: The destruction of articular cartilage is the major cause of articular problems. The articular cartilage has little repair postertial due to lack of perichondrium and direct blood circulation. It is, therefore important to consider this phenomena in surgical treatments. One of the articular cartilage reconstructive surgeries is using Osteo-Chondral graft. The main purpose of this re...
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Articular cartilage is known to have poor healing capacity after injury. Autologous chondral grafting remains the mainstay to treat well-defined, full-thickness, symptomatic cartilage defects. We demonstrated the utilization of gelatin microbeads to deliver autologous chondrocytes for in vivo cartilage generation. Chondrocytes were harvested from the left forelimbs of 12 Lee-Sung pigs. The cell...
متن کاملComparison of cartilage self repairs and repairs with costal and articular chondrocyte transplantation in treatment of cartilage defects in rats.
In our experiment, we tried to assess the potential of repair of full-thickness defects in articular cartilages of rabbit femurs. An artificially made, full-thickness defect in the rabbit's femoral patellar groove was created. The defects were divided into six groups. The reparative tissue was evaluated by macroscopic, histological, and immunohistochemical examinations. The reparative tissues i...
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ژورنال
عنوان ژورنال: International Orthopaedics
سال: 2006
ISSN: 0341-2695,1432-5195
DOI: 10.1007/s00264-006-0120-0